Healthspan expert, Rhonda Patrick, discusses the benefits of coffee in her podcast.

5 Coffee Facts from Her Podcast

Coffee and Epigenetic Aging Regular coffee drinkers have significantly younger epigenetic age signatures, meaning their DNA behaves as if it's younger [02:16]. Studies show that each additional cup of coffee can correspond to about 0.12 years younger biological age [02:42].
Coffee and Cardiovascular Health Coffee significantly reduces cardiovascular disease risk by about 10 to 15% and protects against heart attacks, stroke, and cardiovascular-related death [04:45]. Contrary to past beliefs, caffeine in coffee appears to reduce the risk of developing arrhythmias in a dose-dependent manner [05:01].
Optimal Coffee Timing Consuming coffee exclusively in the morning shows significant longevity benefits, including a 12% lower risk of death from all causes and a 31% lower risk of cardiovascular-related death, compared to spreading caffeine throughout the day [05:31]. Caffeine consumed late in the day can disrupt the internal circadian clock, leading to delayed melatonin release and compromised sleep quality [06:16].
Brewing Method Matters Filtered coffee is consistently the best choice for longevity and overall health, as it traps oily compounds called durpen that can raise LDL cholesterol [16:05]. Unfiltered methods like French press or espresso allow these durpen to enter the coffee, potentially increasing cardiovascular risk and, at very high consumption levels, have been associated with slightly elevated risks of certain cancers [16:15].
Coffee and Gut Health Each cup of coffee delivers soluble fiber and a variety of beneficial compounds like polyphenols and chlorogenic acids, which can significantly shape the gut microbiome [13:43]. A sweet spot of two to four cups a day reliably enriches short-chain fatty acid-producing bacteria, contributing to lower inflammation and improved insulin sensitivity [15:13].